FORSKNING Danmark
Der er meget lidt materiale på dansk – og nedenstående artikel er ikke forskning men en opsummering på udenlandske erfaringer og behandlinger.
Ikke desto mindre er det desværre meget af grundlaget for den (manglende og ikke-opdateret) behandling man kan få i Danmark.
2016: Behandling og håndtering af kongenitte melanocytære naevi
Forfatter(e)Kamille-Amalie Bahn1, Merete Hædersdal2, Grethe Schmidt3 & Lisbet Rosenkrantz Hölmich1 1) Plastikkirurgisk Afdeling, Herlev-Gentofte Hospital 2) Dermatologisk Afdeling, Bispebjerg Hospital 3) Klinik for Plastik-kirurgi, Brystkirurgi og Brandsårsbehandling, Rigshospitalet Ugeskr Læger 2016;178:V04160243
Nedenstående artikel er 30 års opsummerede danske erfaringer med >kun 35< tilfælde af CMN i Danmark.
2015: Giant Congenital Melanocytic Nevus: Report From 30 Years of Experience in a Single Department
Rasmussen, Bo Sonnich MD*; Henriksen, Trine Foged MD, PhD†; Kølle, Stig-Frederik Trojahn MD*; Schmidt, Grethe MD*
Annals of Plastic Surgery: February 2015 – Volume 74 – Issue 2 – p 223-229
FORSKNING UDLAND
UK: Især Prof. Kinsler fra UK har foretaget en del målrettet CMN forskning i UK.
- Does the gene matter? Genotype-phenotype and genotype-outcome associations in congenital melanocytic naevi.
- Longitudinal study of congenital melanocytic naevi reveals that final colour is determined by normal skin colour, and is unaltered by superficial removal techniques.
- Predictors of Health-related Quality of Life and Psychological Adjustment in Children and Adolescents With Congenital Melanocytic Nevi: Analysis of Parent Reports.
- MEK inhibition appears to improve symptom control in primary NRAS-driven CNS melanoma in children.
- Melanoma in congenital melanocytic naevi.
- Widespread dynamic and pleiotropic expression of the melanocortin-1-receptor (MC1R) system is conserved across chick, mouse and human embryonic development.
- The patterns of birthmarks suggest a novel population of melanocyte precursors arising around the time of gastrulation
- Melanoma in congenital melanocytic naevi
- MEK inhibition appears to improve symptom control in primary NRAS-driven CNS melanoma in children.
- This paper looks at whether infantile haemangiomas (strawberry birthmarks) are commoner in people with CMN which had been suggested in the past – it turns out that they aren’t.
- This collaborative paper with Klaus Busam’s group in New York shows that a particular pathology staining test can help work out if a nodule in a CMN is melanoma rather than a benign proliferative nodule.
- This paper shows that a particular genetic test on a biopsy from CNS (brain or spine) disease can help work out if it is melanoma rather than benign neurological disease.
- Growth and Hormonal Profiling in Children with Congenital Melanocytic Naevig
- Acute Inhibition of MEK Suppresses Congenital Melanocytic Nevus Syndrome in a Murine Model Driven by Activated NRAS and Wnt Signaling
- Classification of neurological abnormalities in children with congenital melanocytic naevus syndrome identifies MRI as the best predictor of clinical outcome
- Next-Generation Sequencing of Nevus Spilus-Type Congenital Melanocytic Nevus: Exquisite Genotype-Phenotype Correlation in Mosaic RASopathies
- Immunohistochemical and ultrastructural features of congenital melanocytic naevus cells support a stem cell phenotype
- Multiple Congenital Melanocytic Naevi and Neurocutaneous Melanosis are Caused by Post-Zygotic Mutations in Codon 61 of NRAS
- Germline Melanocortin-1-Receptor Genotype Is Associated with Severity of Cutaneous Phenotype in Congenital Melanocytic Nevi: A Role for MC1R in Human Fetal Development
- The face in congenital melanocytic nevus syndrome
- Neuropathology of neurocutaneous melanosis: histological foci of melanotic neurons and glia may be undetectable on MRI
- Satellite lesions in congenital melanocytic nevi – time for a change of name
- The role of surgery in the management of congenital melanocytic naevi in children: a perspective from Great Ormond Street Hospital
- Great Ormond Street Hospital for Children Registry for Congenital Melanocytic Naevi: prospective study 1988-2007. Part 2- Evaluation of treatments
- Great Ormond Street Hospital for Children Registry for Congenital Melanocytic Naevi: prospective study 1988-2007. Part 1 – epidemiology, phenotype and outcomes
- Complications of congenital melanocytic naevi in children: analysis of 16 years’ experience and clinical practice
Schweiz: Især Dr. Schiestl fra Schweiz og hans team på Kinderspital Zürich har foretaget en del målrettet CMN forskning:
Multidisciplinary long‐term care and modern surgical treatment of congenital melanocytic nevi–recommendations by the CMN surgery network
H Ott, S Krengel, O Beck, K Boehler… – JDDG: Journal der …, 2019 – Wiley Online Library
In recent years, our knowledge of congenital melanocytic nevi (CMN) has greatly expanded.
This has led to a paradigm shift. The present article represents a commentary by an
interdisciplinary group of physicians from German‐speaking countries with extensive …
Citeret af 13 Relaterede artikler Alle 7 versioner
Malignant melanoma in a large congenital melanocytic nevus 9 years after dermabrasion in childhood
G Dragieva, J Hafner, W Künzi, R Dummer… – …, 2006 – search.proquest.com
The term large CMN is used for lesions measuring 1 9 cm at birth which predicts a diameter
of 1 20 cm in adulthood [1]. These lesions are rare and have an estimated incidence of 1 in
20,000 newborns. CMN of a so-called ‘bathing-suit extension’are extremely rare and occur …
Citeret af 25 Relaterede artikler Alle 5 versioner
[PDF] caringmattersnow.co.uk
Predictors of health-related quality of life and psychological adjustment in children and adolescents with congenital melanocytic nevi: analysis of parent reports
O Masnari, K Neuhaus, T Aegerter… – Journal of pediatric …, 2019 – academic.oup.com
Objectives This cross-sectional study assessed health-related quality of life (HRQOL) and
psychological adjustment in children and adolescents affected by congenital melanocytic
nevi (CMN) and identified potential predictors of adjustment. Methods Participants were …
Citeret af 11 Relaterede artikler Alle 6 versioner
[PDF] uzh.ch
Skin‐related quality of life in children and adolescents with congenital melanocytic naevi–an analysis of self‐and parent reports
K Neuhaus, MA Landolt, M Theiler… – Journal of the …, 2020 – Wiley Online Library
Background Congenital melanocytic naevi (CMN) may affect patient quality of life (QoL) due
to medical complications (development of malignant melanoma or involvement of the central
nervous system), skin‐related discomfort or psychosocial sequelae. Objectives To analyse …
Citeret af 6 Relaterede artikler Alle 4 versioner
Surgical treatment of children and youth with congenital melanocytic nevi: self-and proxy-reported opinions
K Neuhaus, M Landolt, M Vojvodic… – Pediatric surgery …, 2020 – Springer
Purpose The role of surgery in the management of congenital melanocytic nevi (CMN) is
controversial. Data on surgical outcomes and predictors of satisfaction remain scarce.
Methods An online survey was employed following worldwide recruitment of youth aged 14 …
Relaterede artikler Alle 5 versioner
[HTML] karger.com
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Coexpression of SOX10/CD271 (p75NTR) and β-Galactosidase in Large to Giant Congenital Melanocytic Nevi of Pediatric Patients
MJ Barysch, MP Levesque, P Cheng, MB Karpova… – …, 2014 – karger.com
Background: Congenital melanocytic nevi (CMNs) are melanocytic neoplasms that can
transform into melanoma. However, this development is impeded in the majority of cases
and mostly affects patients with large or giant CMNs. Methods: To elucidate mechanisms …
Citeret af 6 Relaterede artikler Alle 11 versioner
The positive effect of negative pressure: vacuum-assisted fixation of Integra artificial skin for reconstructive surgery
D Stiefel, CM Schiestl, M Meuli – Journal of pediatric surgery, 2009 – Elsevier
Abstract Background Integra artificial skin (Integra)(Integra Life Sciences Corporation,
Plainsboro, NJ) is increasingly used as a skin substitute in reconstructive surgery. However,
reliable fixation to the wound bed, a factor of paramount importance for successful …
Citeret af 73 Relaterede artikler Alle 8 versioner
[PDF] psu.edu
Self-and parent-perceived stigmatisation in children and adolescents with congenital or acquired facial differences
O Masnari, MA Landolt, J Roessler… – Journal of plastic …, 2012 – Elsevier
Background The risk of social stigmatisation is an important determinant in the decision for
plastic and reconstructive surgery in children and adolescents. The purposes of this cross-
sectional study were threefold:(1) to assess self-and proxy-reported stigma experiences of …
Citeret af 97 Relaterede artikler Alle 11 versioner
Integra Artificial Skin® for burn scar revision in adolescents and children
D Stiefel, C Schiestl, M Meuli – Burns, 2010 – Elsevier
Abstract Integra Artificial Skin®, a biosynthetic dermal template, is well established in acute
burn surgery. The aim of the study was to determine the role of Integra in the surgical
treatment of postburn scars in a younger population. Between March 1998 and November …
Citeret af 137 Relaterede artikler Alle 7 versioner
[HTML] oup.com
Stigmatization predicts psychological adjustment and quality of life in children and adolescents with a facial difference
O Masnari, C Schiestl, J Rössler… – Journal of pediatric …, 2013 – academic.oup.com
Objectives This cross-sectional study assessed psychological adjustment and health-related
quality of life (HRQOL) in children and adolescents with congenital or acquired facial
differences and identified potential predictors of adjustment. Methods Data were obtained …
Citeret af 115 Relaterede artikler Alle 14 versioner